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Vascular health and aging are the most important health care problem in the world today. Healthy aging requires healthy arteries and a healthy heart. Cardio NAD+ is a state-of-the-art solution which uses the most novel ingredients available to help optimize cardiovascular health. As one of the most important systems in your body, we have designed this combination to be synergistic to the many different areas of cardiovascular health while demonstrating cardioprotective effects including the emerging connection between NAD+ and heart health. 

Featured Supportive Benefits: 

  • Improves net NAD+ status by supporting both its synthesis and limiting its degradation 
  • Supports healthy blood pressure 
  • Improves vascular aging and endothelial function
  • Supports healthy fibrinolytic activity and clotting function
  • Promotes healthy circulation and blood flow 
  • Inhibits platelet & red blood cell aggregation
  • Decreases blood viscosity
  • Supports clinical measures of inflammation 
  • Supports healthy blood sugar and insulin levels
  • Inhibits lipid peroxidation
  • Supports healthy lipid metabolism
  • Demonstrated reduction in various independent cardiovascular risk factors

First, we have also included NAD3®, a new and novel ingredient which uses a different approach to manage cardiovascular factors while having positive influences on the hallmarks of aging.  NAD3® is a unique blend of Wasabi japonica extract, theacrine and copper(I)-niacin complex. It turbocharges enzymes that boost the conversion of NAD+ precursors to NAD+ while also suppressing the activity proteins that deplete NAD+.  While you may be familiar with NAD+ supplements for longevity. This product has been designed to also help modulate inflammation and reduce lipids in our blood associated with heart disease. Compared to placebo, at a dose of only 312mg daily, NAD3® lead to significant changes in multiple cardiovascular risk factors (-19%VLDL, -16%LDL, -12%Tot Chol) with a safe, well-tolerated dietary supplement that also demonstrated multiple additional benefits related to healthy aging and cellular longevity.  NAD3® may improve NAD+ status by supporting its synthesis and limiting its degradation, in addition to activating the downstream signaling pathways of longevity, while minimizing the chronic stress of aging. The end result is to try to slow down biological aging by playing both “offense” (amplifying the stress-resilience/ longevity genes), and “defense” (by mitigating the molecular and biochemical hallmarks of aging).  A recent published study demonstrated NAD3® can positively alter molecular markers related to lipid metabolism, cardiometabolic health and hallmarks of aging. NAD3® is a multi-mechanistic solution for healthy aging, mitochondrial performance, cellular longevity.

Second, we have designed ingredient combinations to help with some of the physical components of heart health such as blood pressure and blood viscosity.  For this we have included NSK-SD® (Nattokinase) as an ingredient to help support healthy levels of inflammation, reduce the potential for clots, and to optimize blood pressure backed by over 30 published studies over 25 years of research.   This natural ingredient purified from soybeans has shown to reduce systolic blood pressure by 13.55 points in just 4 weeks. In vitro experiments and human studies suggest that nattokinase may improve blood flow, decrease blood viscosity, reduce the stickiness of red blood cells, and inhibit platelet aggregation. 

Cardio NAD+ also includes AmealPeptide® which was discovered over the course of around 40 years of continuous research into the physiological functions of fermented milk, produced during the process of manufacturing the lactic acid drink CALPIS®.  AmealPeptide® consists of two lactotripeptides - Valine-Proline-Proline (VPP) and Isoleucine-Proline-Proline (IPP).

Key features include its blood pressure-lowering effects and ability to improve cardiovascular functions. AmealPeptide® has an inhibitory activity against angiotensin converting enzyme (ACE). It works on blood vessels by inhibiting enzymes that cause elevated blood pressure and by stimulating production of nitric oxide (NO), which helps to protect blood vessels. These two peptides have substantial effects on improving vascular endothelial dysfunction, vasodilatation, decreases muscle soreness and improves blood flow throughout the body. 

In addition to this,  a newer version of curcumin called tetrahydrocurcumin (4-HC) as been added. It has been documented that curcumin has many cardiovascular benefits. Tetrahydrocurcumin is more bioavailable and as a result, supports better reductions in inflammation. Studies show that tetrahydrocurcumin yields a significant reduction in serum and liver cholesterol, triglycerides, and free fatty acids while supporting healthy levels of inflammation. It also reduces VLDL and LDL cholesterol levels and is more active than curcumin for antihyperlipidemic effects.

Citrus Bergamot, an aromatic fruit from southern Italy, has been added to the formula.  ​ Bergamot has been shown to support a variety of cardio-metabolic biomarkers such as cholesterol, triglycerides, LDL and HDL in several studies. 

This combination of natural ingredients provides the best protection for one of the largest causes of death in the world by supporting lipids, improving cardiovascular mechanics by optimizing blood pressure and helping resolve systemic inflammation.

AmealPeptide® is a registered trademark of Asahi Soft Drinks Co., Ltd. Tokyo, Japan

NAD3® is patent-pending and under exclusive global distribution by Compound Solutions, Inc.

SK-SD® is a registered trademark of Japan BioScience Laboratory, Co., Ltd.

CurcuPrime® is a registered trademark of NNB Nutrition 



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    Citrus Bergamot:

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    • Huang Y, Tocmo R, Nauman MC, Haughan MA, Johnson JJ. Defining the Cholesterol Lowering Mechanism of Bergamot (Citrus bergamia) Extract in HepG2 and Caco-2 Cells. Nutrients. 2021 Sep 10;13(9):3156. doi: 10.3390/nu13093156. PMID: 34579033; PMCID: PMC8469228.

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