Calocurb – Amarasate (90 Caps)

THE WORLDS FIRST PATENTED GLP-1

ACTIVATING SUPPLEMENT

Calocurb is a weight management supplement that has been developed over a period of more than 13 years at the New Zealand Institute for Plant & Food Research, with the support of $25 million in government funding. Its efficacy is attributed to its active ingredient, Amarasate® , which is an extract from a specific variety of NZ hop flower - identified as having the ability to activate & enhance the body’s natural feeling of fullness or satiety. 

Amarasate ® is released into the small intestine, specifically the duodenum, from a delayed release patented capsule.

After only one hour, it stimulates the TAS2R receptors on enteroendocrine cells to release gastric hormones (GLP-1 and CCK) at 6 times baseline levels, twice the normal post-prandial release. 

Clinically shown to:

• Reduce caloric intake by an average of 18%
• Reduce changes in hunger by up to 100%
• Reduce changes in cravings by up to 120%

Suggested Use:

The standard recommendation is to take one capsule daily for 2-3 days & build up to two capsules 1 hour prior to a meal. Up to four capsules can be taken per day Dosing may be tailored depending on a patients requirements such as a specific diet or hunger times. Up to 4 capsules can be taken to reach the recommended dose.

Known Side Effects:

Taking Calocurb for the first time may cause a mild stomach irritation and a laxative effect which should cease after 24-48 hours of use. This effect is based on the presence & activity of the cells responding to the Amarasate ® stimulation which is why it is advised to build up the dosage over three days.

Statements & Warnings:

Due to the nature of the human clinical trials, results are based on adult dietary intake. This product is intended for adults only. Calocurb should not be taken by individuals that have any form of gastrointestinal inflammation or inflammatory bowel disease, such as Crohn's or ulcerative colitis. Calocurb is not indicated for patients with type 1 diabetes mellitus.

Mode of Action:

Calocurb's journey began with the discovery of Amarasate® in 2013, a groundbreaking, potent extract that has been demonstrated to stimulate the enhanced release of satiety hormones.

Amarasate® is a natural extract of New Zealand bitter hops that has been demonstrated in clinical trials to regulate & reduce appetite, craving & caloric intake.

 Amarasate ® is released into the small intestine, specifically the duodenum, from a delayed release patented capsule (Walker et al., 2022)

• After only one hour, it stimulates the TAS2R receptors on enteroendocrine cells to release gastric hormones (GLP-1 and CCK) at six times baseline levels, twice the normal post-prandial release (Walker et al., 2022). 
• These gastric hormones signal a part of the brain to decrease appetite and food cravings plus slow down the gastric emptying rate.