Biohacking with Peptides: A Holistic Guide to Health Optimisation
•Posted on November 14 2025
In recent years, the fields of biohacking and health optimisation have unveiled exciting strategies like the use of peptides and bioregulators. These emerging therapies promise benefits in weight management, healing, and overall bodily function enhancement. Today, we delve into these breakthroughs alongside expert insights from holistic nutritionist and biohacking enthusiast, Natalie Nidham.
Understanding Peptides and Bioregulators
Peptides, made of short chains of amino acids, play a significant role as signaling molecules, influencing a variety of health-promoting pathways. Bioregulators, meanwhile, consist of even shorter chains, often only two to four amino acids long, which interact with DNA to regulate gene expression and restore cellular homeostasis.
Mitochondrial Health and Repair
Key Peptides
- MOXIE: Mimics exercise effects to enhance mitochondrial function.
- HUMININ: Acts similarly to calorie restriction, promoting metabolic health.
- SS31: Facilitates mitochondrial biogenesis and repairs existing structures.
While mitochondrial peptides offer promising boosts to cellular energy production, it’s crucial to prepare the mitochondria through nutrition and lifestyle before introducing these compounds.
Weight Management with Peptides
Semaglutide and co have gained attention as peptides aiding in weight loss by enhancing insulin sensitivity and reducing cravings. These compounds engage GLP-1 pathways in the brain, which help modulate appetite and metabolic processes. Importantly, they should be paired with a high-quality, nutrient-dense diet and monitored to minimize any potential side effects.
Exploring other supplements such as Healthgevity’s "Ignite", which combines several smart compounds for metabolic enhancement, may further complement peptide therapies.
Healing and Recovery
BPC-157
Known as the Swiss Army knife of peptides, Body Protective Compound 157 (BPC-157) aids in gastrointestinal healing, reduces inflammation, and enhances recovery across various tissues. It is effective both orally and through subcutaneous injections.
GHK-CU (Copper Peptide)
With a focus on skin regeneration and reducing fibrosis, GHK-CU peptides offer practical benefits. They improve wound healing, enhance collagen production, and have been linked to cognitive improvements.
Community and Resources for Biohacking
For those venturing into peptide and biohacking strategies, joining a knowledgeable community can be invaluable. Natalie Nidham's BSP Community provides in-depth courses, expert Q&As, and a space to explore case studies in a collaborative environment.
For comprehensive peptide guidance, consider accessing her Peptide Crash Course, which provides critical insights into effective use and protocol customisation.
Conclusion: Embrace the Future of Health Optimisation
The frontier of health optimisation continues to expand with advances in peptide research and personalized medicine. As studies evolve, embracing new therapeutic methods like peptides and bioregulators could significantly impact longevity and quality of life. Pursue these paths with informed caution and a commitment to understanding the complex symphony of your body's needs.
Listen to Lisa's full interview with leading Biohacker Nathalie Niddam on her youtube channel here: